The era of Big Data and analytics is upon us. Recent advances in data capture, real-time analysis, and data-driven decision-making have given rise to a rapid proliferation of data analytics across various business functions and sectors. The health care sector is one such industry in the economy which is ripe for innovations in the research and application of analytical methodologies. Key developments over the past few years have paved the way toward applying analytical methodologies in health care. First, progress in the collection and digitization of health care data is happening at a rapid pace. Second, there is renewed managerial and policy focus on delivering quality health care at affordable costs, wearable technology, drug compliance, etc. Given the increased focus of data and analytics in health care, there is clear need for research in understanding the role and boundaries of data-driven decision-making in health care.